Basically once the immune system makes antibodies, it also makes "secondary" or "anti-ideotype" antibodies that binds to the primary antibodies. Some of these will be molecular mimics of the spike protein, i.e. they will bind to the same molecules and potentially have similar adverse effects.
Secondary antibodies are not usually a big deal, but given that the genetic vax strategy involves maintaining astronomically high antibody titers (much higher than with natural infection) that could elevate the effects of secondary antibodies.
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branchandroot
Re: Improved diagnosis - whacky blood?
Date: 2022-04-13 06:48 pm (UTC)https://www.nejm.org/doi/full/10.1056/NEJMcibr2113694
Basically once the immune system makes antibodies, it also makes "secondary" or "anti-ideotype" antibodies that binds to the primary antibodies. Some of these will be molecular mimics of the spike protein, i.e. they will bind to the same molecules and potentially have similar adverse effects.
Secondary antibodies are not usually a big deal, but given that the genetic vax strategy involves maintaining astronomically high antibody titers (much higher than with natural infection) that could elevate the effects of secondary antibodies.
Mark L