Well, there's the Teapot Dome Scandal which rocked the Harding Administration. I also just finished reading about the Bonus Army where President Hoover's handling of the vets looking for an early payout of their bonus gave his administration enough of a black eye (along with his ham-handed handling of the Depression) to help him lose the election to Franklin Roosevelt.

JLfromNH/Citrine Insouciant Armadillo